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The ENACT Grand Rounds, a monthly seminar series hosted by the ENACT Network, fosters learning on real-world data (RWD) and real-world evidence (RWE) generation, promoting an Open Science and Data Sharing culture. The series accelerates scientific discovery and improves translational research efficiency, quality, and impact by exploring Electronic Health Records (EHR) in solving problems like secondary data analysis, surveillance, learning healthcare systems, and policy. Attendees will learn from case examples using ENACT synthetic datasets, distributed analytics, and cohort discovery, showcasing experts from the CTSA Consortium and beyond.